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TCA cycle is amphibolic (both catabolic and anabolic) in nature.

* TCA cycle is amphibolic (both catabolic and anabolic) in nature. There is a continuous influx (pouring into) and a continuous efflux (removal) of4-carbon units from the TCA cycle.

*Catabolic role(energy production):

• Glucose ——– > pyruvate ——- > Acetyl CoA —— > enters into TCA cycle
• Oxaloacetate ——– > precursor of aspartate
• Glutamate —— > alpha ketoglutarate

*Anabolic role:

• Citrate ——- > cholesterol and fatty acid synthesis
• Alpha ketoglutarate —— > glutamuc acid –— > GABA
• Succinyl CoA ——– > heme synthesis and ketolysis
• Malate / oxaloacetate ———- > gluconeogenesis