TCA cycle is amphibolic (both catabolic and anabolic) in nature.

* TCA cycle is amphibolic (both catabolic and anabolic) in nature. There is a continuous influx (pouring into) and a continuous efflux (removal) of4-carbon units from the TCA cycle.

*Catabolic role(energy production):

• Glucose ——– > pyruvate ——- > Acetyl CoA ——> enters into TCA cycle
• Oxaloacetate ——–> precursor of aspartate
• Glutamate —— > alpha ketoglutarate

*Anabolic role:

• Citrate ——→cholesterol and fatty acid synthesis
• Alpha ketoglutarate ——> glutamuc acid –—> GABA
• Succinyl CoA ——– >heme synthesis and ketolysis
• Malate / oxaloacetate ———→ gluconeogenesis