Muscle glycogen cannot contribute to blood glucose.
- Glucose-6-phosphatase converts glucose-6-phosphate to glucose
- Muscle tissue lacks glucose-6-phosphatase enzyme(this enzyme is present in liver) so it cannot convert glucose-6-phosphate to glucose
- Glucose-6-phosphate, which is release from muscle glycogen, will goes to liver and converted to glucose.
- So muscle tissue cannot directly contribute for blood glucose, it's need help of liver enzyme for coversion from glucose - 6 phosphate to glucose.
- Glucose-6-phosphate undergoes glycolysis in muscle tissue to produce ATP for muscle contraction
or
- Muscle does not contain glucose 6 phosphatase enzyme thus glycogen can not be converted into free glucose and released into circulation.
- Unlike muscle glycogen, Liver glycogen has glucose 6 phosphatase serves as storage and can be converted into free glucose and released into blood circulation and maintain blood glucose levels.