GLUCOSE IS GIVEN IN TREATMENT OF ACUTE INTERMITTENT PORPHYRIA

• ACUTE INTERMITTENT PORPHYRIA is inherited as an autosomal dominant trait.
• Deficiency of= PBG deaminase (UPG-1 synthase) leads to Accumulation of ALA and Porphobilinogen leads to Oxidative damage to CNS and neurotoxic effects

Effect of Glucose

1. On ALA synthase :Inhibits Biosynthesis
2. On Succinyl Co-A : Uses up succinyl Co-A in TCA cycle