DIARRHOEA CAUSES NORMAL ANION GAP ACIDOSIS

• DIARRHOEA : Excessive loss of intestinal secretions,fluid and electrolytes in stool.
• ANION GAP : Difference between concentration of Cations and Anions present within blood.
• Anion Gap = (Na• + K•)-(HCO3 - + Cl-)
• Actually the unmeasured anions present in trace amount constitute the aniongap.{12mmol/L}.

OR

• Diarrhoea —→ Loss of intestinal fluids —→ Loss of bicarbonate (HCO₃⁻) in stool —→ Decrease in plasma bicarbonate —→ Metabolic acidosis develops —→ Kidneys retain chloride (Cl⁻) to maintain electro neutrality —→ ↑ Chloride (Hyperchloremic) —→ Na⁺ − (Cl⁻ + HCO₃⁻) remains normal —→ NORMAL ANION GAP (Hyperchloremic) METABOLIC ACIDOSIS