2,4 - dinitrophenol (uncoupler ) leads to thermogenesis.

• 2,4 -dinitrophenol (uncoupler) dissipates energy in the form of heat instead of ATP in oxodative phosphorylation.
• It carries proton across inner mitochondrial membrane. This dissipates proton gradient without passing through ATP synthesis.
• Electron transport and oxygen consumption continue but ATP synthesis decreases

• Thus, energy from oxidation is released as heat instead of ATP leading to thermogenesis.