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tca_cycle_is_amphibolic_in_nature [2025/12/30 05:49]
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-*TCA cycle is amphibolic (both catabolic and anabolic) in nature. There is a continuous influx (pouring into) and a continuous efflux (removal) of4-carbon units from the TCA cycle.+**TCA cycle is amphibolic (both catabolic and anabolic) in nature.** 
 + 
 +* TCA cycle is amphibolic (both catabolic and anabolic) in nature. There is a continuous influx (pouring into) and a continuous efflux (removal) of4-carbon units from the TCA cycle.
  
 *Catabolic role(energy production): *Catabolic role(energy production):
-     *Glucose -------> pyruvate ------->Acetyl CoA ------ > enters into TCA cycle +  *Glucose -------- > pyruvate ------- > Acetyl CoA ------> enters into TCA cycle 
-     *Oxaloacetate --------> precursor of aspartate +  *Oxaloacetate --------> precursor of aspartate 
-     *Glutamate ------>alpha ketoglutarate+  *Glutamate ------ > alpha ketoglutarate
 *Anabolic role: *Anabolic role:
-     *Citrate ------->cholesterol and fatty acid synthesis +  *Citrate ------->cholesterol and fatty acid synthesis 
-     *Alpha ketoglutarate ------ > glutamuc acid –--- > GABA +  *Alpha ketoglutarate ------> glutamuc acid –---GABA 
-     *Succinyl CoA -------->heme synthesis and ketolysis +  *Succinyl CoA -------- >heme synthesis and ketolysis 
-     *Malate / oxaloacetate ---------- > gluconeogenesis+  *Malate / oxaloacetate ----------> gluconeogenesis
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