g6pd_deficient_patient_are_resistant_to_falciparum_malaria

G6PD-deficient patients are resistant to Plasmodium falciparum malaria

  • because their red blood cells (RBCs) have reduced levels of NADPH , leading to oxidative stress.
  • Due to oxidative stress , structure of RBC weakens,causing their premature destruction (hemolysis)
  • so that the parasite can’t complete its life cycle.
  • This natural selection advantage explains the higher prevalence of G6PD deficiency in malaria-endemic regions.

OR

  • Decreased activity of G6PD impairs Hexose Monophosphate[HMP)Shunt. Thus there is no synthesis of NADPH as well as no formation of reduce glutathione in RBC for protecting it from stress.
  • Malaraial parasites require NADPH for its optimal growth.
  • Hence, parasite survival is reduced against severe falciparum malaria infected RBCs.
  • g6pd_deficient_patient_are_resistant_to_falciparum_malaria.txt
  • Last modified: 2025/12/30 07:27
  • by admin