**TCA cycle is amphibolic (both catabolic and anabolic) in nature.**

* TCA cycle is amphibolic (both catabolic and anabolic) in nature. There is a continuous influx (pouring into) and a continuous efflux (removal) of4-carbon units from the TCA cycle.

*Catabolic role(energy production):
  *Glucose -------- > pyruvate ------- > Acetyl CoA ------> enters into TCA cycle
  *Oxaloacetate --------> precursor of aspartate
  *Glutamate ------ > alpha ketoglutarate
*Anabolic role:
  *Citrate ------->cholesterol and fatty acid synthesis
  *Alpha ketoglutarate ------> glutamuc acid –---> GABA
  *Succinyl CoA -------- >heme synthesis and ketolysis
  *Malate / oxaloacetate ----------> gluconeogenesis