g6pd_deficient_patient_are_resistant_to_falciparum_malaria [LSSTH - Laboratory Services Sir T Hospital, Bhavnagar]

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**G6PD-deficient patients are resistant to Plasmodium falciparum malaria** 

  * because their **red blood cells (RBCs) have reduced levels of NADPH** , leading to oxidative stress. 
  * Due to oxidative stress , structure of RBC weakens,causing their premature destruction (hemolysis) 
  * so that the parasite can’t complete its life cycle. 
  * This natural selection advantage explains the higher prevalence of G6PD deficiency in malaria-endemic regions.

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**OR**

   *Decreased activity of G6PD impairs Hexose Monophosphate[HMP)Shunt. Thus there is no synthesis of NADPH as well as no formation of reduce glutathione in RBC for protecting it from stress.
   *Malaraial parasites require NADPH for its optimal growth.
   *Hence, parasite survival is reduced against severe falciparum malaria infected RBCs.