Show pageOld revisionsBacklinksBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. **Ethanol consumption induces depression.** *Ethanol enhances the inhibitory action of GABA in the brain, mainly at the GABA_A receptor. *GABA is the major inhibitory neurotransmitter in the CNS.----->GABA_A receptors are ligand-gated chloride (Cl⁻) channels------>Ethanol acts as a positive allosteric modulator of the GABA_A receptor (does not replace GABA).----->In presence of ethanol, GABA binding increases opening frequency of Cl⁻ channels.----->Increased Cl⁻ influx → hyperpolarization of neuronal membrane.------>Hyperpolarization reduces neuronal excitability and firing. *Result → CNS depression. ethanol_consumption_induces_depression.txt Last modified: 2025/12/30 06:11by admin