carbohydrate_are_essential_for_the_metabolism_of_fat [LSSTH - Laboratory Services Sir T Hospital, Bhavnagar]

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**Carbohydrate are essential for the metabolism of Fat.**

*For complete oxidation of fatty acids , we need oxaloacetate. Fatty acids are broken down in to Acetyl CoA by beta oxidation. For oxidation to occur it needs oxaloacetate which is derived from carbohydrate metabolism.
     * acetyl CoA requires oxaloacetate to enter into TCA cycle
     *Glucose → Pyruvate → Oxaloacetate (via pyruvate carboxylase)
* If carbohydrate ids deficient , then oxaloacetate which is generated is diverted to
gluconeogenesis. Thus there will be less Oxaloacetate available for TCA cycle, and Acetyl CoA cant be fully oxidized.
*Thus there will be accumulation of Acetyl CoA and it will be directed to ketogenesis.
*Also carbohydrates provide glycerol-3-phosphate through glycolysis.
    *-Glycerol-3-phosphate is essential for:
    *Esterification of fatty acids
    *Formation of triglycerides
*Without carbohydrates, fatty acids cannot be properly stored as triglycerides.