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--- proteolytic_enzyme_are_released_in_zymogen_form [2025/12/18 10:49]
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+++ proteolytic_enzyme_are_released_in_zymogen_form [2025/12/26 09:26] (current)
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-  * HDL is the main transport form of cholesterol from peripheral tissue to liver, which is later excreted through bile .This is called reverse cholesterol transport by HDL.
+  *Proteolytic enzymes can digest cellular proteins; if secreted in active form, they may cause autodigestion, especially of pancreas and gastric mucosa.Hence, these enzymes are synthesized and secreted as zymogens (inactive precursors).
-  * Excretion of cholesterol needs prior esterification with PUFA. Thus PUFA will help in lowering of cholesterol in the body,and so PUFA is anti-atherogenic
+  *Zymogens lack proteolytic activity, preventing tissue damage . This mechanism protects enzyme-producing cells, pancreatic tissue, and gastric mucosa from self-digestion.
-  * The level of HDL in serum is inversely related to the incidence of myocardial infarction. As it is "anti-atherogenic" or protective in nature, HDL is known as "good cholesterol in common parlance"
+  *Zymogens are activated only at the site of action by limited proteolysis, e.g
+     *Pepsinogen → Pepsin (by HCl in stomach)
-{{|img_4090.jpeg?400 |}}
+     *Trypsinogen → Trypsin (by enterokinase in intestine)
-{{ ::enzyme.docx |}}