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ethanol_consumption_induces_depression [2025/12/30 06:11]
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ethanol_consumption_induces_depression [2025/12/30 06:11] (current)
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| *GABA is the major inhibitory neurotransmitter in the CNS.----->GABA_A receptors are ligand-gated chloride (Cl⁻) channels------>Ethanol acts as a positive allosteric modulator of the GABA_A receptor (does not replace GABA).----->In presence of ethanol, GABA binding increases opening frequency of Cl⁻ channels.----->Increased Cl⁻ influx → hyperpolarization of neuronal membrane.------>Hyperpolarization reduces neuronal excitability and firing. | *GABA is the major inhibitory neurotransmitter in the CNS.----->GABA_A receptors are ligand-gated chloride (Cl⁻) channels------>Ethanol acts as a positive allosteric modulator of the GABA_A receptor (does not replace GABA).----->In presence of ethanol, GABA binding increases opening frequency of Cl⁻ channels.----->Increased Cl⁻ influx → hyperpolarization of neuronal membrane.------>Hyperpolarization reduces neuronal excitability and firing. |
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| *Result → CNS depression. | *Result → CNS depression. |