carbohydrate_are_essential_for_the_metabolism_of_fat

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carbohydrate_are_essential_for_the_metabolism_of_fat [2025/12/30 06:03] (current)
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 +**Carbohydrate are essential for the metabolism of Fat.**
  
 +*For complete oxidation of fatty acids , we need oxaloacetate. Fatty acids are broken down in to Acetyl CoA by beta oxidation. For oxidation to occur it needs oxaloacetate which is derived from carbohydrate metabolism.
 +     * acetyl CoA requires oxaloacetate to enter into TCA cycle
 +     *Glucose → Pyruvate → Oxaloacetate (via pyruvate carboxylase)
 +* If carbohydrate ids deficient , then oxaloacetate which is generated is diverted to
 +gluconeogenesis. Thus there will be less Oxaloacetate available for TCA cycle, and Acetyl CoA cant be fully oxidized.
 +*Thus there will be accumulation of Acetyl CoA and it will be directed to ketogenesis.
 +*Also carbohydrates provide glycerol-3-phosphate through glycolysis.
 +    *-Glycerol-3-phosphate is essential for:
 +    *Esterification of fatty acids
 +    *Formation of triglycerides
 +*Without carbohydrates, fatty acids cannot be properly stored as triglycerides.
  • carbohydrate_are_essential_for_the_metabolism_of_fat.txt
  • Last modified: 2025/12/30 06:03
  • by admin